Table 1

Tissue instability index predicted by a PLSR model.

Tissue

Instability index

Tissue

Instability index


dorsal striatum

6.37

cornea

0.29

liver

5.63

common myeloid progenitor

0.29

kidney

1.17

follicular B-cells

0.27

Adrenal gland

1.13

skeletal muscle

0.27

amygdala

1.10

dendritic plasmacytoid B220+

0.26

hypothalamus

1.08

granulo mono progenitor

0.24

retina

0.99

macrophage peri LPS thio 0 hrs

0.22

cerebral cortex

0.98

ciliary bodies

0.17

cerebellum

0.96

mast cells

0.16

mega erythrocyte progenitor

0.96

osteoblast day5

0.14

lens

0.95

bone marrow

0.12

NK cells

0.89

pituitary

0.10

dendritic cells lymphoid CD8a+

0.88

pancreas

0.09

macrophage bone marrow 6 hr LPS

0.85

B-cells marginal zone

0.08

T-cells foxP3+

0.85

hippocampus

0.07

stomach

0.82

lacrimal gland

0.06

dorsal root ganglia

0.75

lymph nodes

0.04

macrophage bone marrow 24 h LPS

0.74

spinal cord

0.03

macrophage bone marrow 2 hr LPS

0.72

mammary gland lact

0.01

macrophage peri LPS thio 1 hrs

0.71

osteoblast day 14

-0.15

cerebral cortex prefrontal

0.69

salivary gland

-0.20

T-cells CD4+

0.63

uterus

-0.24

macrophage peri LPS thio 7 hrs

0.59

mammary gland non-lactating

-0.25

mast cells IgE

0.57

spleen

-0.26

thymocyte DP CD4+CD8+

0.57

intestine small

-0.29

iris

0.57

bone

-0.29

T-cells CD8+

0.49

eyecup

-0.30

osteoclasts

0.48

adipose white

-0.39

macrophage bone marrow 0 hr

0.47

granulocytes mac1+gr1+

-0.39

thymocyte SP CD8+

0.46

osteoblast day 21

-0.39

mast cells IgE+antigen 1 hr

0.43

ovary

-0.47

adipose brown

0.43

bladder

-0.54

dendritic cells myeloid CD8a-

0.41

epidermis

-0.61

mast cells IgE+antigen 6 hr

0.39

intestine large

-0.67

retinal pigment epithelium

0.34

placenta

-0.73

thymocyte SP CD4+

0.33

lung

-0.82

prostate

0.30

heart

-1.01

microglia

0.30

testis

-1.03

olfactory bulb

0.30

umbilical cord

-1.18


The PLSR model built with the instability-correlated gene expression signature from 16 training tissues was used to predict instability index for each of the tissues analyzed in the GNF mouse Gene Expression Atlas. Data represents mean of 2 replicates.

Lee et al. BMC Systems Biology 2010 4:29   doi:10.1186/1752-0509-4-29

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