Open Access Research article

A novel approach to investigate tissue-specific trinucleotide repeat instability

Jong-Min Lee*, Jie Zhang, Andrew I Su, John R Walker, Tim Wiltshire, Kihwa Kang, Ella Dragileva, Tammy Gillis, Edith T Lopez, Marie-Josee Boily, Michel Cyr, Isaac Kohane, James F Gusella, Marcy E MacDonald and Vanessa C Wheeler*

BMC Systems Biology 2010, 4:29  doi:10.1186/1752-0509-4-29

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Note added in proof

JONG-MIN LEE   (2010-04-15 14:56)  Massachusetts General Hospital email

While this paper was in revision Goula et al. (PLoS Genet. 2009 December; 5(12): e100074)ublished findings in which they showed that the stoichiometry of base excision repair (BER) roteins differed in striatum compared to cerebellum in an HD fragment mouse odel. It would therefore be of interest to determine whether these findings extend to a roader correlation between tissue instability and BER protein stoichiometry across a wide range of tissues.

Competing interests

None declared


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