Email updates

Keep up to date with the latest news and content from BMC Systems Biology and BioMed Central.

Open Access Research article

A novel approach to investigate tissue-specific trinucleotide repeat instability

Jong-Min Lee*, Jie Zhang, Andrew I Su, John R Walker, Tim Wiltshire, Kihwa Kang, Ella Dragileva, Tammy Gillis, Edith T Lopez, Marie-Josee Boily, Michel Cyr, Isaac Kohane, James F Gusella, Marcy E MacDonald and Vanessa C Wheeler*

BMC Systems Biology 2010, 4:29  doi:10.1186/1752-0509-4-29

PubMed Commons is an experimental system of commenting on PubMed abstracts, introduced in October 2013. Comments are displayed on the abstract page, but during the initial closed pilot, only registered users can read or post comments. Any researcher who is listed as an author of an article indexed by PubMed is entitled to participate in the pilot. If you would like to participate and need an invitation, please email info@biomedcentral.com, giving the PubMed ID of an article on which you are an author. For more information, see the PubMed Commons FAQ.

Note added in proof

JONG-MIN LEE   (2010-04-15 14:56)  Massachusetts General Hospital email

While this paper was in revision Goula et al. (PLoS Genet. 2009 December; 5(12): e100074)ublished findings in which they showed that the stoichiometry of base excision repair (BER) roteins differed in striatum compared to cerebellum in an HD fragment mouse odel. It would therefore be of interest to determine whether these findings extend to a roader correlation between tissue instability and BER protein stoichiometry across a wide range of tissues.

Competing interests

None declared

top

Post a comment