Table 6

Genes with somatic mutations regulate both mRNA and miRNA expressions, and formed triangle regulation cycles.

Mutation

Gene expression

miRNA expression


Gene

Gene

Damage value

P-value for gene expression

Up or down regulated

miRNA

Damage value

P-value for miRNA expression

Up or down regulated


RB1

LAMP2

0

8.22E-07

Up

hsa-mir-340

0

1.16E-06

Down


DST

OTUB1

0

5.33E-07

Down

hsa-mir-15b

45

1.30E-06

Up


FN1

SSR2

0

3.67E-07

Up

hsa-mir-125a

2

4.83E-05

Down


FN1

TDG

3

5.21E-07

Up

hsa-mir-125a

2

4.83E-05

Down


TP53

TP53

23

1.40E-07

Up

hsa-mir-504

1

1.42E-06

Down


Mutation-gene regression

miRNA-gene regression

Mutation-miRNA regression


Regression coefficient

P-value

Coefficient of determination

Regression coefficient

P-value

Coefficient of determination

Regression coefficient

P-value

Coefficient of determination


1.03E+00

7.04E-04

6.47E-02

-2.77E+02

3.17E-06

8.50E-02

1.81E+00

4.10E-09

1.85E-01


1.23E+00

5.91E-04

6.65E-02

-2.28E+01

9.77E-07

9.34E-02

1.27E+00

3.80E-04

7.18E-02


1.54E+00

1.02E-05

1.07E-01

-2.33E+02

4.92E-05

6.52E-02

-1.18E+00

8.72E-04

6.33E-02


1.39E+00

7.60E-05

8.72E-02

-6.91E+01

4.77E-05

6.54E-02

-1.18E+00

8.72E-04

6.33E-02


2.81E-01

3.30E-02

2.62E-02

-4.14E+01

2.72E-06

8.61E-02

3.43E-01

9.10E-03

3.93E-02


Dong et al. BMC Systems Biology 2010 4:163   doi:10.1186/1752-0509-4-163

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