Representation of predictions in the network. This figure shows parts of the network where the predictions considered in the section 'Discussion' are located. It helps backtracking the source of each prediction. Part A. Predictions on TGFBR2 mRNA and protein are deduced from the observation on EWS-FLI1. The prediction about BCL2 mRNA is deduced from the prediction about IGFBP3, deduced from the prediction about the IGF1 protein which, in turn, is deduced from the observation on AKT1 mRNA. The prediction about the TP73 protein is deduced from the observation on PDGFRB mRNA and serves, together with the observation on CDKN1C mRNA, as a source of the prediction about the IGF2 protein and subsequently - about IGF2 mRNA. The prediction about the family of proteins (.RAS) is deduced from the prediction about the IGFBP3 protein and, together with the prediction about the IGF1 protein, is a source of the prediction on family of proteins (PIK3C.). Part B. Prediction about the JUN protein is deduced from the observation on JUN mRNA and serves as a source for the prediction about the TP53 mRNA. Prediction about the FASLG is a forward deduction from the observation on the FASLG mRNA. Part C. Prediction about the (RAC.) family of proteins is deduced as the only possible explanation of the combination of observations on (RHO.) mRNA family and the phenotypic node [Cell Migration]. Part D. Prediction on phosphorylation of RB1 is a forward deduction from the prediction on PRKCB1 which is deduced from the observation on PRKCB1 mRNA. Part E. The prediction about the CDC2 protein is a result of the correlated interactions of its precursors, predictions on complexes ((CCNA.)^ p:CDC2)) and (CCNB1^ p:CDC2).
Baumuratova et al. BMC Systems Biology 2010 4:146 doi:10.1186/1752-0509-4-146