Additional file 14.

Predicted metabolic fluxes consistent with Bozdech gene expression data mapped onto metabolic pathways. Flux distributions have been predicted with our improved flux balance approach (see Figure 1) for each time point of the intraerythrocytic developmental cycle for which a gene expression profile exists. Simulations were conducted on the basis of the combined metabolic network of parasite and host and additional constraints reflecting knowledge about the blood stage. Furthermore, the expression status of genes during preceding time points was considered for the flux calculations. In order to explore the predicted flux distributions on the level of metabolic pathways, we mapped the flux profiles onto KEGG pathways and counted active reactions, to assess whether a pathway is active or not and wether there are changes during the IDC. The darker the color of a matrix entry the fewer reactions of the corresponding pathway are active.

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Huthmacher et al. BMC Systems Biology 2010 4:120   doi:10.1186/1752-0509-4-120