Additional file 12.

Normalized Hamming distance matrix for calculated flux distributions using improved approach. Flux distributions have been predicted with our improved flux balance approach (see Figure 1) for each time point of the intraerythrocytic developmental cycle for which a gene expression profile exists. Simulations were conducted on the basis of the combined metabolic network of parasite and host and additional constraints reflecting knowledge about the blood stage. Furthermore, the expression status of genes during preceding time points was considered for the flux calculations. In order to compare the individual flux distributions normalized Hamming distances (see text for formula) have been determined for all pairs of flux distributions. The darker the color of a matrix entry, the lower is the corresponding Hamming distance.

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Huthmacher et al. BMC Systems Biology 2010 4:120   doi:10.1186/1752-0509-4-120