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Open Access Methodology article

Simulation methods with extended stability for stiff biochemical Kinetics

Pau Rué12, Jordi Villà-Freixa1* and Kevin Burrage34*

Author Affiliations

1 Computational Biochemistry and Biophysics Group, Research Unit on Biomedical Informatics, IMIM/Universitat Pompeu Fabra, c/Dr. Aiguader 88, 08003, Barcelona, Catalonia, Spain

2 Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Edifici GAIA, Rambla de Sant Nebridi s/n 08222, Terrassa, Barcelona, Spain

3 Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia

4 COMLAB and OCISB, University of Oxford, Oxford OX1 3QD, UK

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BMC Systems Biology 2010, 4:110  doi:10.1186/1752-0509-4-110

Published: 11 August 2010

Additional files

Additional file 1:

Supplementary material for "Simulation methods with extended stability for stiff biochemical kinetics". Technical results, coefficients for the optimal stability polynomials and notes on the mitogen-activated protein kinase (MAPK) cascade simulation results.

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