Table 2

Practical identifiability analysis for the experimental scheme ES1 with () represents the nominal value for the parameters; δREF is the parameter mean value computed by the Monte-Carlo based approach; δREF is the relative distance between the mean and the nominal computed as , corresponds to the predicted maximum uncertainty of the given parameter and represents the uncertainty with respect to μREF in %.

Parameter

θ*

μREF

δREF (in %)

(in %)


t1

0.10

1.77

1680

1.79

100.7


t2

0.10

6.16

6060

3.03

49.1


c3a

4.00 10-4

4.00 × 10-5

3.09

2.80 × 10-5

6.90


c4a

0.50

0.50

0.60

0.08

15.9


c5

3.00 × 10-4

3.07 × 10-4

2.49

1.02 × 10-4

33.1


k1

2.50 × 10-3

2.45 × 10-3

2.04

5.34 × 10-4

21.7


k2

0.10

0.13

33.3

0.08

60.2


k3

1.50 × 10-3

1.18 × 10-3

21.1

8.08 × 10-4

68.3


kprod

2.50 × 10-5

3.25 × 10-5

29.9

3.19 × 10-5

98.3


kdeg

1.25 × 10-4

1.63 × 10-4

33.4

1.62 × 10-4

99.9


i1

2.50 × 10-3

2.40 × 10-3

3.85

6.38 × 10-4

26.5


e2a

0.01

4.74 × 10-3

374

5.30 × 10-3

110.9


i1a

1.00 × 10-3

9.74 × 10-4

0.75

2.42 × 10-4

24.3


Balsa-Canto et al. BMC Systems Biology 2010 4:11   doi:10.1186/1752-0509-4-11

Open Data