Table 1

Best fit parameter set for ligand L144.

Species

Input

n

k

Input

n

k

Input

n

k

τ

zap70

tcrphosp

2

0.29

lck

1

0.33

ccbl

1

0.30

2.77

tcrphosp

tcr

1

0.34

lck

1

0.34

fyn

1

0.13

0.03

tcr

TCRlig

1

0.20

ccbl

1

0.41

0.59

slp76

gads

1

0.35

0.24

sek

pkcth

1

0.26

0.01

rsk

erk

3

0.30

1.00

rlk

lck

1

0.36

1.02

rasgrp

pkcth

1

0.40

dag

1

0.39

2.76

ras

rasgrp

3

0.33

grb2sos

17

0.39

7.50

raf

ras

3

0.31

11.80

plcgbind

lat

5

0.36

0.01

plcgact

zap70

1

0.10

slp76

1

0.29

rlk

1

0.24

0.01

plcgbind

1

0.31

itk

2

0.34

pkcth

dag

2

0.31

8.66

pagcsk

tcr

1

0.32

fyn

1

0.69

1.33

nfkb

ikb

3

0.30

1.00

nfat

calcen

1

0.37

5.03

mek

raf

1

0.28

0.01

TCRlig

ext. sig.

1

0.12

1.28

lck

pagcsk

2

0.30

cd4

2

0.37

cd45

1

0.33

0.15

lat

zap70

3

0.14

0.01

jun

jnk

3

0.30

1.00

jnk

sek

4

0.57

0.08

itk

zap70

2

0.10

slp76

1

0.31

0.01

ip3

plcgact

2

0.38

0.01

ikkbeta

pkcth

18

0.33

10.55

ikb

ikkbeta

3

0.30

1.00

grb2sos

lat

8

0.46

5.26

gads

lat

1

0.36

0.12

fyn

tcr

6

0.27

lck

2

0.30

cd45

4

0.37

0.46

fos

erk

3

0.30

1.00

erk

mek

2

0.28

0.10

dag

plcgact

3

0.28

0.01

creb

rsk

3

0.30

1.00

cre

creb

3

0.30

1.00

cd4

ext. sig.

1

0.32

2.25

cd45

ext. sig.

1

0.35

1.64

ccbl

zap70

1

0.70

0.29

calcen

ca

11

0.30

4.53

ca

ip3

3

0.33

0.20

ap1

jun

3

0.30

fos

3

0.30

1.00

The bold entries are the parameters downstream of all measured species. They were not affected by the optimization process.

Wittmann et al. BMC Systems Biology 2009 3:98   doi:10.1186/1752-0509-3-98