Figure 4.

Comparison between experimental and simulated data. In the figures in the left column, y axes are activities of Erk1/2; In the figures in the right column, y axes are activities of Akt1. In each figure, blue diamonds represent real data; green triangles represent the results of simulation, where we set weights of both activation and blockage edges to 0.8; red squares represent the data of simulation, where we set weights of activation edges to 0.8 and blockage edges to 0.5. The caption above each figure indicates the x and y variables. Figures of D and E report the results for the 100% stimulation of remaining receptors. In simulation, we also included a correction for the cross-stimulation between IR and IGF-1R, according to Table S1.