Figure 9.

TPEs discriminate territory-specific downstream differentiation genes. Groups of genes driven by the Endomesoderm GRN (genes from the lower part of Figure 1) are differently effected by upstream perturbations in simulations. These effects are consistent with the embryonic territory these genes are associated with. The top 6 genes are associated with PMC, the next 3 with mesoderm and the 2 bottom genes with endoderm. TPEs for different timepoints were collated. Red indicates decrease in expression, green indicates increase in expression, dark green indicates a late increase in expression, white indicates no change in expression in response to perturbation.