Table 1

Features of Possibilistic MFA and alternative approaches

Feature

TMFA

LS-MFA

FS-MFA

Monte Carlo

PMFA

Considers irreversible reaction

x

x

x

x

Usable in scenarios lacking measurements

x

o

x

Includes a check of consistency

x

-

-

o

x

Flexible description of measurements errors

-

x

x

Richer estimations (not only point-wise)

-

x

x

Computational efficiency

x

x

x

x

Possibilistic MFA (PMFA) is compared with four approaches for metabolic flux analysis, Traditional MFA (TMFA), MFA as a constraint least-squares problem (LS-MFA) and the flux spectrum approach (FS-MFA). Legend: (x) provided feature, (-) partially provided feature and (o) potentially provided feature.

Llaneras et al. BMC Systems Biology 2009 3:79   doi:10.1186/1752-0509-3-79