Table 4 |
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Predicted genes for Cluster A and B form the "no evidence" group |
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|
Cluster |
Category |
Gene Symbol |
Gene Name |
|
|
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|
A |
Top 10 |
ETS2 |
v-ets erythroblastosis virus E26 oncogene homolog 2 |
|
MTF1 |
metal-regulatory transcription factor 1 |
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|
SAMSN1 |
SAM domain, SH3 domain and nuclear localization signals 1 |
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|
IVNS1ABP |
influenza virus NS1A binding protein |
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|
IFNGR2 |
interferon gamma receptor 2 |
||
|
PLAUR |
plasminogen activator, urokinase receptor |
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|
IL1R2 |
interleukin 1 receptor, type II |
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|
AZIN1 |
antizyme inhibitor 1 |
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|
EHD1 |
EH-domain containing 1 |
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|
PCNX |
pecanex homolog |
||
|
|
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|
Related to innate immunity |
IFNGR2 |
interferon gamma receptor 2 |
|
|
IL1R2 |
interleukin 1 receptor, type II |
||
|
MAP4K4 |
mitogen-activated protein kinase kinase kinase kinase 4 |
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|
NCF1 |
neutrophil cytosolic factor 1 |
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|
TXN |
thioredoxin |
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|
RIPK2 |
receptor-interacting serine-threonine kinase 2 |
||
|
|
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|
Supported by other evidence |
IFNGR2* |
interferon gamma receptor 2 |
|
|
GPR84** |
G protein-coupled receptor 84 |
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|
FCAR** |
Fc fragment of IgA, receptor for |
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|
GADD45B** |
growth arrest and DNA-damage-inducible, beta |
||
|
|
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|
B |
Top 10 |
TRIM5 |
tripartite motif-containing 5 |
|
GK |
glycerol kinase |
||
|
SP110 |
SP110 nuclear body protein |
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|
TMEM140 |
transmembrane protein 140 |
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|
CHMP5 |
chromatin modifying protein 5 |
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|
RHBDF2 |
rhomboid 5 homolog 2 |
||
|
SAMD9 |
sterile alpha motif domain containing 9 |
||
|
DDX58 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
||
|
TLE3 |
transducin-like enhancer of split 3 |
||
|
TRIM21 |
tripartite motif-containing 21 |
||
|
|
|||
|
Related to innate immunity |
CSF2RB |
colony stimulating factor 2 receptor, beta, low-affinity |
|
|
HCK |
hemopoietic cell kinase |
||
|
IL13RA1 |
interleukin 13 receptor, alpha 1 |
||
|
TLR1 |
toll-like receptor 1 |
||
|
TNFRSF1A |
tumor necrosis factor receptor superfamily, member 1A |
||
|
|
|||
|
Supported by other evidence |
DDX5*** |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 |
|
|
HERC5*** |
hect domain and RLD 5 |
||
|
IFIT2*** |
interferon-induced protein with tetratricopeptide repeats 2 |
||
|
OASL*** |
2'-5'-oligoadenylate synthetase-like |
||
|
SNX10*** |
sorting nexin 10 |
||
|
ACSL4*** |
acyl-CoA synthetase long-chain family member 4 |
||
|
|
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|
The ten most correlated target genes, as well as genes related to innate immunity (from the fifty most correlated genes) and genes which were supported by other evidence, are shown. *Predicted as a target gene from the motif sequence analysis. **DNA-protein binding detected in LPS stimulation. ***Up-regulated by a mutant of STAT1 which can activate expression in the absence of tyrosine phosphorylation. |
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|
Seok et al. BMC Systems Biology 2009 3:78 doi:10.1186/1752-0509-3-78 |
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