Table 3

Significant network communities that are enriched with target genes of miRNA clusters.

Chr

Cluster

Network Community

Function

3(-)

let-7

ACTA1, DRP2, SNTA1, DMD, DAG1, SNTB2, UTRN, SNTG1, SNTG2, KCNJ12, SNTB1, PGM5P1, DTNA, DTNB, DGKZ

muscle development and contraction

13(+)

mir-17

AR, ESR1, RB1, TP53, CREBBP, EP300, JUN, STAT3, NCOA1, SMAD4, SMAD2, SMAD3, BRCA1, STAT1, TRIP4, RELA, CCND1, SP1

positive regulation of transcription

14(+)

mir-379

ARNTL, PER1, TIMELESS, CRY1, CLOCK, PER3, CRY2, PER2, CSNK1D, CSNK1E

circadian rhythm

19(+)

mir-512

HDAC2, RBBP7, RBP1, SAP30, HDAC1, ING1, RBBP4, BRMS1, SIN3A, BRMS1L, C2ORF59

histone deacetylase

X(-)

mir-450

TP53, CUL5, COPS3, GPS1, COPS2, COPS8, COPS6, COPS5, COPS4, COPS7A

cancer suppressor p53 with COP9 signalosome

Yuan et al. BMC Systems Biology 2009 3:65   doi:10.1186/1752-0509-3-65