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Open AccessHighly AccessResearch article

Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi

Seth B Roberts1,2 email, Jennifer L Robichaux3 email, Arvind K Chavali3 email, Patricio A Manque1,2 email, Vladimir Lee1 email, Ana M Lara1,2 email, Jason A Papin3 email and Gregory A Buck1,2 email

1Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia 23298, USA

2Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia 23298, USA

3Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA

author email corresponding author email

BMC Systems Biology 2009, 3:52doi:10.1186/1752-0509-3-52

Published: 16 May 2009

Additional files

Additional file 1:

Additional tables. Four worksheets, including detailed reaction list for iSR215, complete listing of metabolite names and abbreviations, full results from proteomics experiments, and lethal reaction deletions (single and non-trivial double) using full model and epimastigote model.

Format: XLS Size: 743KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 2:

iSR215 in SBML format. iSR215 in SBML format.

Format: XML Size: 124KB Download file

Additional file 3:

T. cruzi core metabolic network. Map illustrating the core metabolic network in T. cruzi.

Format: PDF Size: 128KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional file 4:

Flux distribution for full model. Graphical depiction of flux distribution for full model.

Format: PDF Size: 134KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional file 5:

Flux distribution for epimastigote model. Graphical depiction of flux distribution for epimastigote model.

Format: PDF Size: 134KB Download file

This file can be viewed with: Adobe Acrobat Reader


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