BMC Systems Biology

official impact factor 3.57

Open Access Highly Access Research article

Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi

Seth B Roberts1,2, Jennifer L Robichaux3, Arvind K Chavali3, Patricio A Manque1,2, Vladimir Lee1, Ana M Lara1,2, Jason A Papin3* and Gregory A Buck1,2*

Author Affiliations

1 Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia 23298, USA

2 Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia 23298, USA

3 Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA

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BMC Systems Biology 2009, 3:52 doi:10.1186/1752-0509-3-52

Published: 16 May 2009

Additional files

Additional file 1:

Additional tables. Four worksheets, including detailed reaction list for iSR215, complete listing of metabolite names and abbreviations, full results from proteomics experiments, and lethal reaction deletions (single and non-trivial double) using full model and epimastigote model.

Format: XLS Size: 743KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

iSR215 in SBML format. iSR215 in SBML format.

Format: XML Size: 124KB Download file

Open Data

Additional file 3:

T. cruzi core metabolic network. Map illustrating the core metabolic network in T. cruzi.

Format: PDF Size: 128KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

Flux distribution for full model. Graphical depiction of flux distribution for full model.

Format: PDF Size: 134KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 5:

Flux distribution for epimastigote model. Graphical depiction of flux distribution for epimastigote model.

Format: PDF Size: 134KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data