Interaction Network of Phenotypes and Environmental Factors. Phenotypes are represented as circular nodes and environmental factors as diamond shaped nodes. Edges represent sharing at least two significantly enriched pathways (p ≤ 0.003) using lists of genes associated with a particular phenotype or environmental factor, according to the phenotype-gene relationships in the Genetic Association Database  or the environmental factor-gene relationships found in the Comparative Toxicogenomics Database, respectively. MeSH IDs are used as environmental factor node labels. Environmental factors with pharmacological or toxicological action in the MeSH record are color coded based on broad phenotype categories according to annotation in Additional file 2. *Phenotypes which do not fit into a specific category or environmental factors with undetermined pharmacological or toxicological action are gray. Request the Cytoscape session file of this network from Julia Gohlke firstname.lastname@example.org for more detailed exploration. Annotation of the circled metabolic syndrome and neuropsychiatric subnetworks can be found in Additional file 3.
Gohlke et al. BMC Systems Biology 2009 3:46 doi:10.1186/1752-0509-3-46