Figure 3.

Frequency of condition-specific activity for top regulators. Many TFs were likely to be mediating transcriptional responses in multiple conditions. Given that the set of conditions in our study was enriched by those in which metabolism of various amino acids or nucleotides was directly or indirectly perturbed and by conditions causing DNA damage, it was not surprising that the list of most frequently active regulators included ArgR, GcvA, CysB, MetR/MetJ, DeoR, PurR, LexA.