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Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

Jesse J Smith1†, Renée D Kenney2†, David J Gagne1, Brian P Frushour2, William Ladd2, Heidi L Galonek1, Kristine Israelian1, Jeffrey Song1, Giedre Razvadauskaite1, Amy V Lynch1, David P Carney1, Robin J Johnson2, Siva Lavu1, Andre Iffland1, Peter J Elliott1, Philip D Lambert1, Keith O Elliston2, Michael R Jirousek1, Jill C Milne1 and Olivier Boss1*†

Author Affiliations

1 Sirtris, a GSK company 200 Technology Square, Cambridge, MA, 02139, USA

2 Genstruct Inc, One Alewife Center, Cambridge, MA, 02140, USA

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BMC Systems Biology 2009, 3:31 doi:10.1186/1752-0509-3-31

Published: 10 March 2009

Additional files

Additional file 1:

Causal network model knowledgebase. This file contains the knowledge used in this CNM effort.

Format: ZIP Size: 17KB Download file

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Additional file 2:

Supplemental data and legends. Supplemental data and legends contains figures detailing state changes underlying many key nodes that were identified in by CNM but were not described in the main text.

Format: PDF Size: 230KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data