Research article
Efficiency of complex production in changing environment
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* Corresponding author: Shai Carmi scarmi@shoshi.ph.biu.ac.il
1 Minerva Center & Department of Physics, Bar-Ilan University, Ramat Gan, Israel
2 Center for Polymer Studies, Boston University, Boston, MA, USA
3 Department of Genetics, Harvard Medical School, Boston, MA, USA
4 Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv, Israel
BMC Systems Biology 2009, 3:3 doi:10.1186/1752-0509-3-3
Published: 7 January 2009Additional files
Additional file 1:
A list of the complexes. The file contains a list of all complexes (extracted from MIPS, 2007). Each row in the file contains the systematic names of the proteins in one complex.
Format: TXT Size: 70KB Download file
Additional file 2:
Extended discussion. The file contains complementary discussion of few specific points. • A list of complexes with uniform response to change of environmental conditions, and an analysis of their properties in view of their role in cell cycle. • A discussion of the relation between our findings to the dosage balance hypothesis. • Model results for the optimal response to transition to minimal media when all subunits are allowed to change. • Illustration that complex proteins have lower noise. • A discussion of alternative hypotheses that could explain the low noise in large complexes, the high level of the least abundant protein in a complex, and the similarity of transcript length in a complex.
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