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Open Access Software

FORG3D: Force-directed 3D graph editor for visualization of integrated genome scale data

Jussi Paananen12* and Garry Wong12

Author Affiliations

1 A.I. Virtanen Institute of Molecular Sciences, University of Kuopio, Kuopio, Finland

2 Department of Biosciences, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland

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BMC Systems Biology 2009, 3:26  doi:10.1186/1752-0509-3-26

Published: 24 February 2009

Abstract

Background

Genomics research produces vast amounts of experimental data that needs to be integrated in order to understand, model, and interpret the underlying biological phenomena. Interpreting these large and complex data sets is challenging and different visualization methods are needed to help produce knowledge from the data.

Results

To help researchers to visualize and interpret integrated genomics data, we present a novel visualization method and bioinformatics software tool called FORG3D that is based on real-time three-dimensional force-directed graphs. FORG3D can be used to visualize integrated networks of genome scale data such as interactions between genes or gene products, signaling transduction, metabolic pathways, functional interactions and evolutionary relationships. Furthermore, we demonstrate its utility by exploring gene network relationships using integrated data sets from a Caenorhabditis elegans Parkinson's disease model.

Conclusion

We have created an open source software tool called FORG3D that can be used for visualizing and exploring integrated genome scale data.