A fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera aphidicola

doi:10.1186/1752-0509-3-24

BMC Systems Biology

Volume 3

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Research article

A fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera aphidicola

Gavin H Thomas¹^* , Jeremy Zucker²^* , Sandy J Macdonald¹ , Anatoly Sorokin³ , Igor Goryanin³ and Angela E Douglas¹^,4

¹Department of Biology, University of York, PO Box 373, York, YO10 5YW, UK

²Research Computing, Dana Faber Cancer Institute, 44 Binney Street, Boston, MA 0211, USA

³Centre for Intelligent Systems and their Applications, School of Informatics, University of Edinburgh, Appleton Tower, 11 Crichton Street, Edinburgh, EH8 9LE, UK

⁴Department of Entomology, 5136 Comstock Hall, Cornell University, Ithaca, NY 14853, USA

author email corresponding author email* Contributed equally

BMC Systems Biology 2009, 3:24doi:10.1186/1752-0509-3-24


Published:	21 February 2009

Additional files

Additional file 1:

Additional Methods. This file contains additional methods for the construction and validation of the model and the flux correlation method with references.

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Additional file 2:

Quantification of essential amino acid release from B. aphidicola APS. These data demonstrate the contribution of B. aphidicola APS-derived essential amino acids to protein growth of 2-to-7-day-old larval pea aphids (clone LL01) on chemically-defined diets.

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Additional file 3:

Description of the iGH196 model and fluxes from the 5.21 model. The Excel sheet describes the gene/reaction relationships in the model and the fluxes in the 5.21 model.

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Additional file 4:

Analysis of the FBA simulations for non-essential genes. The file summarises the results from our analysis of the FBA simulations for non-essential genes from iGT196 by our own method and also by using the linearMOMA method.

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Additional file 5:

Flux correlation of the histidine and purine biosynthesis pathways. Pairwise scatterplots showing correlation of fluxes in reactions of the histidine and purine biosynthetic pathways of Buchnera aphidicola.

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Additional file 6:

List of APS genes and the frequency of their retention in evolved symbionts. This file lists the APS genes and the frequency of their retention in evolved symbionts from Pal et al,. (2006) and this study.

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