Figure 4.

Simulated acyl-CoA concentrations and experimentally derived acylcarnitine data. Relative simulated concentration of acyl-CoA as a function of carbon chain length for healthy controls (Control) and acyl-CoA dehydrogenase deficiencies (SCADD, MCADD, LCADD, VLCADD). The concentrations are divided by the concentrations of the control group (Controls). Additionally, experimentally derived acylcarnitine data for C4 to C18 of MCAD (expMCADD) and VLCAD (expVLCADD) deficiencies of the Middle Europe dataset are depicted. These data are divided by the concentrations of the corresponding experimental control data. Note that relative concentration values higher than 14 are shown on the top x-axis at carbon lengths of 4, 8 and 14. The experimental data are unlinked anonymous newborn screening data from Germany [28].