Axiom 6 (oriented CELL DIVISION) dysregulation and its effect on ISEA CULTURE growth and morphology. Axiom 6 dictates CELL DIVISION when a CELL has at least one CELL and MATRIX but no FREE SPACE in its neighborhood. The CELL copy is placed at an adjacent MATRIX position that maximizes its number of CELL neighbors. With a parameter-controlled probability, p, CELLS followed an alternate, dysregulated action (disoriented CELL DIVISION) when the Axiom 6 precondition was met. The CELL copy replaced a randomly selected MATRIX neighbor without regard for CELL neighbor number. Doing so caused changes in growth and structural characteristics of the EMBEDDED CULTURE. (A) CELL CULTURE growth rate increased monotonically with the severity of dysregulation. (B) Shown are changes in growth morphology. Similar to Axiom 5 dysregulation, this analogue showed no observable effects during the early growth stage but obvious differences over time. (C-D) Axiom 6 dysregulation altered CELL DIVISION and DEATH event patterns. Near the maximally dysregulated state (p = 0), the system exhibited a proportionately larger increase in CELL DEATH events at later times. The data are mean values of 100 Monte Carlo runs.
Kim et al. BMC Systems Biology 2009 3:122 doi:10.1186/1752-0509-3-122