Table 3

A selection of cancer-unrelated SL partners of cancer-related genes and their associated drugs.

Drug-target name

Drug (Description)

CDC25B

Beta-Mercaptoethanol (Glutathione S-Transferase inhibitor); Cysteinesulfonic Acid(Peroxiredoxin inhibitor); Double Oxidized Cysteine (Peptide Deformylase Pdf1 inhibitor)

CDC42

Aminophosphonic Acid-Guanylate Ester (G25K GTP-Binding Protein inhibitor)

CDK2

4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine (Cell Division Protein Kinase 2 inhibitor)

DDX6

D-tartaric acid (D-tartaric acid)

EIF4E

7-Methyl-Gpppa (Eukaryotic Translation Initiation Factor 4E inhibitor); 7n- Methyl-8-Hydroguanosine-5'-Diphosphate (Vp39 inhibitor)

GDI1

Geran-8-Yl Geran(Rab GDP Disossociation Inhibitor Alpha inhibitor)

GRB2

4- [(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo- 7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid (Growth Factor Receptor-Bound Protein 2 inhibitor)

HSP90AB1

9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine (Heat Shock Protein Hsp 90-Beta inhibitor)

HSPA5

antihemophilic factor (Coagulation factor VIII precursor)

LSS

Dihydrofolic Acid (Dihydrofolate Reductase inhibitor)

PPP1CC

9,10-Deepithio-9,10-Didehydroacanthifolicin (Serine/Threonine Protein Phos phatase Pp1-Gam inhibitor)

PPP2CA

Vitamin E (Dietary supplement)

PPP3R2

Cyclosporine (Investigational Immunomodulatory Agents; Immunosuppressive Agents; Antifungal Agents; Dermatologic Agents; Enzyme Inhibitors; An tirheumatic Agents For treatment of transplant rejection, rheumatoid arthritis, severe psoriasis)

PRDX2

3-Sulfinoalanine (3-Hydroxy-3-Methylglutaryl-Coa Synthase inhibitor)

SEC14L2

Palmitic Acid (Enzyme Inhibitors)

SNAP25

Botulinum Toxin Type A (Anti-Wrinkle Agents; Antidystonic Agents; Neuromuscular Blocking Agents)

SOD1

S-Oxy Cysteine (Prolyl Oligopeptidase inhibitor)

SQLE

Naftifine (Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents)

These drugs are not oriented to anti-cancer treatment. In this list we excluded general metabolites described as dietary supplements in DrugBank. A short description of drug activities are provided in parenthesis.

Conde-Pueyo et al. BMC Systems Biology 2009 3:116   doi:10.1186/1752-0509-3-116