Research article
Human synthetic lethal inference as potential anti-cancer target gene detection
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* Corresponding author: Carlos Rodríguez-Caso carlos.rodriguez@upf.edu
1 ICREA-Complex Systems Lab, Universitat Pompeu Fabra. Parc de Recerca Biomedica de Barcelona, Dr Aiguader 88, E-08003 Barcelona, Spain
2 Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe, NM 87501, USA
BMC Systems Biology 2009, 3:116 doi:10.1186/1752-0509-3-116
Published: 16 December 2009Additional files
Additional file 1:
Detailed information on the statistical analysis of iHSLN biological functions. File in a .xls format.
Format: XLS Size: 283KB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional file 2:
List of 1078 human genes homologous to the 2383 SL yeast genes from the BioGRID database (Figure 5). File in a .xls format.
Format: XLS Size: 358KB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional file 4:
List of SL relations between the inferred human SL genes (iHSLN). File in .sif format to be loaded in cytoscape software. Edges are represented in two columns separated by the label pp.
Format: SIF Size: 52KB Download file
Additional file 5:
The network of SL relations between the inferred human SL genes (iHSLN) (Figure 6). File in .cys format. This file must be opened with cytoscape software.
Format: ZIP Size: 78KB Download file
Additional file 6:
Cancer-related genes and their first neighbors from the SL human network (Figure 7). File in .cys format. This file must be opened with cytoscape software.
Format: ZIP Size: 40KB Download file
Additional file 7:
An extract of SL-inferred human orthologs organized by GO numbers and related with DNA damage and cell-cycle (Figure 8). File in .cys format. This file must be opened with cytoscape software.
Format: ZIP Size: 16KB Download file
Additional file 3:
Sub-network of SL nodes that are also drug targets, and their first SL neighbors. File in .cys format. This file must be opened with cytoscape software.
Format: ZIP Size: 54KB Download file
Additional file 8:
Drug-cancer SL network representing the set of cancer-related nodes and their SL drug-associated partners (Figure 9). File in .cys format. This file must be opened with cytoscape software.
Format: ZIP Size: 68KB Download file