Figure 1.

Schematic of the EGF activated ERK pathway: This is a schematic of the EGF activated ERK pathway beginning at the level of EGF binding to EGFR and finishing at the level of ERK; see the text for more details on the features and functions of the pathway. Mutations to the proteins highlighted in red are well known to result in the constitutive activation of ERK, leading to the subsequent development cancer.