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Open AccessResearch article

Dynamics of receptor and protein transducer homodimerisation

Julio Vera1* email, Thomas Millat1* email, Walter Kolch2,3 email and Olaf Wolkenhauer1 email

University of Rostock, 18051 Rostock, Germany

The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK

University of Glasgow, Sir Henry Wellcome Functional Genomics Facility, Glasgow, G12 8QQ, UK

author email corresponding author email* Contributed equally

BMC Systems Biology 2008, 2:92doi:10.1186/1752-0509-2-92

Published: 31 October 2008

Additional files

Additional file 1:

On the role of receptor and protein homodimerisation in cell signalling Supplementary Material. In the main text the double activation of the receptor is represented by a trimolecular biochemical reaction. The assumptions leading to this simplified representation of receptor activation are explained in detail. Furthermore, the determination of the apparent kinetic order using a power-law approach is discussed here. The supplementary material is provided as PDF-file.

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