BMC Systems Biology

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Open Access Highly Access Research article

Robust simplifications of multiscale biochemical networks

Ovidiu Radulescu1*, Alexander N Gorban2,6, Andrei Zinovyev3,4,5,6 and Alain Lilienbaum7,8

Author Affiliations

1 IRMAR (CNRS UMR 6025) and IRISA/INRIA, Université de Rennes 1, Campus de Beaulieu, 35042 Rennes, France

2 Department of Mathematics, University of Leicester, LE1 7RH, UK

3 Institut Curie, Service Bioinformatique, Paris, 26 rue d'Ulm, Paris F-75248, France

4 INSERM, U900, Paris, F-75248, France

5 Ecole des Mines de Paris, ParisTech, Fontainebleau, F-77300, France

6 Institute of Computational Modeling SB RAS, Krasnoyarsk, Akademgorodok, 660036, Russia

7 Cytosquelette et Développement (CNRS UMR 7000), Faculté de Médecine Pitié-Salpêtrière, 105, boulevard de l'Hôpital, 75634 Paris cedex 13, France

8 Stress et Pathologies du Cytosquelette (EA300), Université Paris 7 Denis Diderot, 4, rue Marie-Andrée Lagroua Weill-Hallé 75013 Paris, France

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BMC Systems Biology 2008, 2:86 doi:10.1186/1752-0509-2-86

Published: 14 October 2008

Additional files

Additional file 1:

Hierarchy of NFκB models. This file shows the hierarchy of models using Systems Biology Graphical Notation (SBGN) and the results of a study of the truly non-linear reactions.

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