BMC Systems Biology
Volume 2
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What ever happened to single photon scintigraphy?
Lionel Zuckier
(05 February 2009) New Jersey Medical School 
Very interesting and comprehensive article. Nonetheless, I was surprised by the complete omission of single-photon imaging, both planar and tomographic. These are powerful techniques with resolution in small animals, such as by microSPECT, superior to that of dual-photon (PET)imaging (though lacking absolute quantification as in PET). These techniques have been used for decades to provide much basic physiologic information by way of imaging and compartmental modeling.
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