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Constructing disease-specific gene networks using pair-wise relevance metric: Application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements

Wei Jiang1* email, Xia Li1,2* email, Shaoqi Rao1,2,3,4 email, Lihong Wang1 email, Lei Du1 email, Chuanxing Li1 email, Chao Wu1 email, Hongzhi Wang5 email, Yadong Wang5 email and Baofeng Yang1 email

College of Bioinformatics Science and Technology and Bio-pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, PR China

Department of Bioinformatics, Capital University of Medical Sciences, Beijing 100084, PR China

Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, PR China

Department of Molecular Cardiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA

Department of Computer Science, Harbin Institute of Technology, Harbin 150080, PR China

author email corresponding author email* Contributed equally

BMC Systems Biology 2008, 2:72doi:10.1186/1752-0509-2-72

Published: 10 August 2008

Additional files

Additional file 1:

The AFV values of the 200 colon cancer-specific gene interactions.

Format: PDF Size: 43KB Download file

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Additional file 2:

Application of the novel network approach to prostate cancer microarray data.

Format: PDF Size: 253KB Download file

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