The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism

doi:10.1186/1752-0509-2-71

BMC Systems Biology

Volume 2

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Nookaew I
Jewett MC
Meechai A
Thammarongtham C
Laoteng K
Cheevadhanarak S
Nielsen J
Bhumiratana S

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Meechai A
Thammarongtham C
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Research article

The genome-scale metabolic model iIN800 of Saccharomyces cerevisiae and its validation: a scaffold to query lipid metabolism

Intawat Nookaew¹ , Michael C Jewett⁵^,6 , Asawin Meechai¹ , Chinae Thammarongtham² , Kobkul Laoteng² , Supapon Cheevadhanarak³ , Jens Nielsen⁵^,7 and Sakarindr Bhumiratana¹^,2^,4

¹Department of Chemical Engineering, Faculty of Engineering, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand

²Biochemical Engineering and Pilot Plant Research and Development Unit, National Center for Genetic Engineering and Biotechnology (BIOTEC) at King Mongkut's University of Technology Thonburi, Bangkhuntien, Bangkok 10150, Thailand

³School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand

⁴National Science and Technology Development Agency, Ministry of Science and Technology, Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand

⁵Center for Microbial Biotechnology, Biocentrum, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark

⁶Department of Genetics, Harvard Medical School, Boston, MA 02115, USA

⁷Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden

author email corresponding author email

BMC Systems Biology 2008, 2:71doi:10.1186/1752-0509-2-71


Published:	7 August 2008

Additional files

Additional file 1:

Additional ORFs. List if additional ORFs and their references containing in iIN800.

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Additional file 2:

Lipid metabolism reactions and comparison. Comparison of lipid metabolism reactions of all S. cerevisiae genome-scale models.

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Additional file 3:

Growth simulation results. Growth simulations and comparison with experimental measurements.

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Additional file 4:

Aerobic Flux distribution. Visualization of flux distribution of aerobic growth mapping on Figure 1.

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Additional file 5:

Anaerobic Flux distribution. Visualization of flux distribution of anaerobic growth mapping on Figure 1.

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Additional file 6:

High resolution file of Figure 1. High resolution of S. cerevisiae metabolic map is provided as EPS format.