Open Access Research article

Impact of the solvent capacity constraint on E. coli metabolism

Alexei Vazquez1*, Qasim K Beg27, Marcio A deMenezes3, Jason Ernst4, Ziv Bar-Joseph4, Albert-László Barabási5, László G Boros6 and Zoltán N Oltvai2*

Author Affiliations

1 The Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA

2 Department of Pathology, University of Pittsburgh, Pittsburgh, PA, 15261, USA

3 Instituto de Física, Universidade Federal Fluminense, Rio de Janeiro, 24210, Brazil

4 Machine Learning Department, Carnegie-Mellon University, Pittsburgh, PA, 15217, USA

5 Department of Physics and Center for Complex Networks Research, University of Notre Dame, South Bend, IN 46556, USA

6 SiDMAP, LLC and the UCLA School of Medicine, Los Angeles, CA 90064, USA

7 Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA

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BMC Systems Biology 2008, 2:7  doi:10.1186/1752-0509-2-7

Published: 23 January 2008

Additional files

Additional file 1:

E. coli metabolic reactions and biomass vector

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Additional file 2:

Measured enzyme activity values for various intracellular enzymes of the central carbon metabolism

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Additional file 3:

Dchip Microarray analysis of biomass samples from all five dilution/growth rates

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Additional file 4:

Impact of the solvent capacity constraint on E. coli metabolism

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Additional file 5:

Flux predictions for 710 reactions in the in silico of E. coli metabolism during growth on glucose-limited medium

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Additional file 6:

List of all genes along with their 'b'-numbers showing similar expression profile with query genes.

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