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Open Access Highly Accessed Commentary

Optimization in computational systems biology

Julio R Banga

Author Affiliations

Instituto de Investigaciones Marinas, CSIC (Spanish Council for Scientific Research), C/Eduardo Cabello 6, 36208 Vigo, Spain

BMC Systems Biology 2008, 2:47  doi:10.1186/1752-0509-2-47

Published: 28 May 2008

Abstract

Optimization aims to make a system or design as effective or functional as possible. Mathematical optimization methods are widely used in engineering, economics and science. This commentary is focused on applications of mathematical optimization in computational systems biology. Examples are given where optimization methods are used for topics ranging from model building and optimal experimental design to metabolic engineering and synthetic biology. Finally, several perspectives for future research are outlined.