Renal and hepatic insulin degradation. Left: Stationary insulin degradation rates of the liver (red) and the kidney (blue) and the total insulin degradation rate (black) are shown as functions of insulin concentration. Right: Stationary relative contributions of the liver (red) and the kidney (blue) to total insulin degradation depend on the insulin concentration. Note that these fractions are slightly lower in reality. Other tissues, in particular fat and muscle, also contribute to insulin degradation but are not analyzed here. The fractions in this plot refer to the sum of the degradation rates of liver and kidney.
Koschorreck and Gilles BMC Systems Biology 2008 2:43 doi:10.1186/1752-0509-2-43