Dynamic model validation: receptor internalization. Simulation results for receptor internalization at 100 nM insulin (blue) as well as those without insulin (red) are shown and compared to experimental data . Surface receptors were radioactively labeled. This was simulated by setting the initial conditions such that all receptors are in the state R at the plasma membrane. Note that the receptor model is linear for constant insulin concentration. Therefore, the assay can be simulated with this choice of initial conditions.
Koschorreck and Gilles BMC Systems Biology 2008 2:43 doi:10.1186/1752-0509-2-43