Table 4
MCS
=
Reduce
(
,
J
,
S
)
1: //
Argument:
2: //
, a collection of cut sets for objective reaction
3: // set
J
⊂
N
in system
S
∈ ℝ
m
×
n
4: //
Output:
5: //
MCS
, a collection of MCS for
J
6:
7:
MCS
,
Done
= empty collection
8:
for all
sets
H
in collection
do
9:
ToDo
= {
H
};
10:
while
ToDo
is not empty
do
11:
= a lowest cardinality set from
ToDo
12: //Apply LP based test to all
13: //immediate subsets of
to determine
14: //which cut
at least one
flux in objective set
J
15:
= collection of size |
| - 1 subsets of
that are also cut sets for objective set
J
in
S
16: add
to collection
Done
17:
if
is empty
then
18: add
to collection
MCS
19:
else if
contains one set
then
20: add sole set in
to
MCS
and
Done
21:
else
22: add sets in
to
ToDo
23:
end if
24: Remove from
ToDo
super sets of any set in collection
Done
25:
end while
26:
end for
27: return
MCS
Imielinski and Belta
BMC Systems Biology
2008
2
:40 doi:10.1186/1752-0509-2-40