Research article

Parameter optimization in S-system models

Marco Vilela^1,⁵^*, I-Chun Chou², Susana Vinga³, Ana TR Vasconcelos⁴, Eberhard O Voit² and Jonas S Almeida^1,⁵

¹ Dept. Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA

² Dept. Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA 30332, USA

³ Instituto de Engenharia de Sistemas e Computadores: Investigação e Desenvolvimento (INESC-ID), R. Alves Redol 9, 1000-029 Lisboa, Portugal

⁴ Dept. Computatinal and Applied Mathematics, Laboratório Nacional de Computação Científica, Petrópolis, Rio de Janeiro, Brazil

⁵ Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Rua da Quinta Grande 6, Apartado 127, 2780-156 Oeiras, Portugal

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BMC Systems Biology 2008, 2:35 doi:10.1186/1752-0509-2-35

Published: 16 April 2008

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