Comparison of the multistart of the generalized-quasi-Newton within single and multiple-shooting for the Goodwin model. Shown is the percentage of convergence to the global minimum, local minima or failure of the optimisation method using 100 restarts. The initial guess of each restart is randomly chosen from interval [0, 100] (Box 100), and [0, 1000] (Box 1000) using a uniform distribution. a) Noise-to-signal ratio is zero. b) Same as in a), but using a noise-to-signal ratio of 10%.
Balsa-Canto et al. BMC Systems Biology 2008 2:26 doi:10.1186/1752-0509-2-26