Email updates

Keep up to date with the latest news and content from BMC Systems Biology and BioMed Central.

Open Access Research article

One hub-one process: a tool based view on regulatory network topology

Jacob Bock Axelsen1, Sebastian Bernhardsson2 and Kim Sneppen3*

Author Affiliations

1 Centro de Astrobiología, Instituto Nacional de Técnica Aeroespacial, Ctra de Ajalvir km 4, 28850 Torrejón de Ardoz, Madrid, Spain

2 Department of Theoretical Physics, Umeå University, 901 87 Umeå, Sweden

3 Center for Models of Life, Niels Bohr Institute, Blegdamsvej 17 DK-2100 Copenhagen Ø, Denmark

For all author emails, please log on.

BMC Systems Biology 2008, 2:25  doi:10.1186/1752-0509-2-25

Published: 4 March 2008



The relationship between the regulatory design and the functionality of molecular networks is a key issue in biology. Modules and motifs have been associated to various cellular processes, thereby providing anecdotal evidence for performance based localization on molecular networks.


To quantify structure-function relationship we investigate similarities of proteins which are close in the regulatory network of the yeast Saccharomyces Cerevisiae. We find that the topology of the regulatory network only show weak remnants of its history of network reorganizations, but strong features of co-regulated proteins associated to similar tasks. These functional correlations decreases strongly when one consider proteins separated by more than two steps in the regulatory network. The network topology primarily reflects the processes that is orchestrated by each individual hub, whereas there is nearly no remnants of the history of protein duplications.


Our results suggests that local topological features of regulatory networks, including broad degree distributions, emerge as an implicit result of matching a number of needed processes to a finite toolbox of proteins.