Table 4

Targets in the H-List that are also involved in drug resistance mechanisms.

Resistance related proteins


Protein

Description

CcdA (Rv0527)

Cytochrome

PolA (Rv1629)

SOS

LldD2 (Rv1872c)

Cytochrome

QcrC (Rv2194)

Cytochrome

QcrB (Rv2196)

Cytochrome

CtaC (Rv2200c)

Cytochrome

Cyp121 (Rv2276)

Cytochrome

Rv3660c (Rv3660c)

HGT


Proteins closely connected to resistance proteins


Protein

Closely connected to

SecY (Rv0732)

DnaE1 (SOS) and SecA1 and SecA2 (HGT)

Rv0843 (Rv0843)

Three cytochrome proteins

Pdc (Rv0853c)

Rv1988 (Antibiotic Efflux Pump) and two cytochromes

Rv1456c (Rv1456c)

Three cytochrome proteins

Rv1711 (Rv1711)

RecA, DnaE1 (SOS proteins) and a cytochrome

Rv1828 (Rv1828)

SecA2 (HGT) and two cytochromes

QcrC (Rv2194)

Four cytochrome proteins

QcrA (Rv2195)

Five cytochrome proteins

QcrB (Rv2196)

Five cytochrome proteins

CtaC (Rv2200c)

Five cytochrome proteins

Cyp121 (Rv2276)

19 cytochrome proteins

HemE (Rv2678c)

Seven cytochrome proteins

FtsK (Rv2748c)

SOS proteins RecA, PolA and DnaE1

RnhB (Rv2902c)

SOS proteins PolA, DnaE1 and DnaE2

TrmD (Rv2906c)

SOS proteins PolA, DnaE1 and Rv2294 (Antibiotic Efflux Pump)

PrfB (Rv3105c)

PolA (SOS) and SecA1 and SecA2 (HGT)

IlvX (Rv3509c)

Three cytochrome proteins

TrxB2 (Rv3913)

RecA (SOS) and two cytochrome proteins


The top panel shows targets that are directly implicated in resistance mechanisms. The lower panel indicates targets which are immediately connected to proteins involved in the emergence of resistance in the interactome. These proteins are predicted to be involved in mediating the flow of information from the targets to the resistance machinery.

Raman et al. BMC Systems Biology 2008 2:109   doi:10.1186/1752-0509-2-109

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