Table 1

EGFR signalling and trafficking.

Species

Rate Equation

Constants

Ref


1

RA

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M1','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M1">View MathML</a>

k1 = 3 × 10-4

k-1 = 0.23

ke = 0.03

kRsyn = 300

[25]

[31]

2

LB

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M2','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M2">View MathML</a>

kLclv = 0.005

kLsyn = 250

[31-33]

3

RLA

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k2 = 0.001

k_2 = 6.0

[15]

4

RL2A

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M4','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M4">View MathML</a>

k3 = 60

k_3 = 0.6

[15]

5

RPA

<a onClick="popup('http://www.biomedcentral.com/1752-0509/2/102/mathml/M5','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1752-0509/2/102/mathml/M5">View MathML</a>

V4 = 2.3 × 106

K4 = 3 × 104

kint = 0.19

[25]


Equations relating to juxtacrine receptor – ligand interaction and receptor dimerisation and phosphorylation. Constants are either extracted directly from, inferred from or reported in the cited references. Units – All parameters relate to numbers of molecules – square brackets are for clarity only. Units are: first order rate constant: min-1; second order rate constants molecules-1 min-1, maximal enzyme rates (Vmax) are expressed in units of molecules min-1, Michaelis constants (Km) in molecules. kRsyn and kLsyn are in no. molecules cell-1 min-1. Conversions from concentrations to numbers of molecules assume a cell volume of 10-12 litres.

Walker et al. BMC Systems Biology 2008 2:102   doi:10.1186/1752-0509-2-102

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