Table 1 

EGFR signalling and trafficking. 

Species 
Rate Equation 
Constants 
Ref 



1 
R_{A} 
k_{1 }= 3 × 10^{4} k_{1 }= 0.23 k_{e }= 0.03 k_{Rsyn }= 300 
[25] [31] 

2 
L_{B} 
k_{Lclv }= 0.005 k_{Lsyn }= 250 

3 
RL_{A} 
k2 = 0.001 k_2 = 6.0 
[15] 

4 
RL2_{A} 
k3 = 60 k_3 = 0.6 
[15] 

5 
RP_{A} 
V4 = 2.3 × 10^{6} K4 = 3 × 10^{4} kint = 0.19 
[25] 



Equations relating to juxtacrine receptor – ligand interaction and receptor dimerisation and phosphorylation. Constants are either extracted directly from, inferred from or reported in the cited references. Units – All parameters relate to numbers of molecules – square brackets are for clarity only. Units are: first order rate constant: min^{1}; second order rate constants molecules^{1 }min^{1}, maximal enzyme rates (V_{max}) are expressed in units of molecules min^{1}, Michaelis constants (K_{m}) in molecules. k_{Rsyn }and k_{Lsyn }are in no. molecules cell^{1 }min^{1}. Conversions from concentrations to numbers of molecules assume a cell volume of 10^{12 }litres. 

Walker et al. BMC Systems Biology 2008 2:102 doi:10.1186/175205092102 