|
Protein complexes with essential functions are not enriched for subunits with over-expression phenotypes. |
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| Percentage genes with over-expression phenotype (total number of genes) |
P-value |
|
|
|
||
| All protein complex subunits |
16% (943) |
|
| Complex with no essential subunits |
18% (255) |
|
| Complex with at least one essential subunit |
15% (688) |
0.28a |
| Complex with >= 25% essential subunits |
16% (447) |
0.56a |
| Complex with >= 50% essential subunits |
15% (371) |
0.24a |
| Essential subunits of protein complex |
14% (342) |
0.24b |
|
a Significance of difference between the subunits of protein complexes with any, >= 25% or >= 50% essential subunits and the subunits of other complexes (Chi square test, 1 dof). b Significance of difference between essential and non-essential subunits of protein complexes (Chi square test, 1 dof). | ||
Semple et al. BMC Systems Biology 2008 2:1 doi:10.1186/1752-0509-2-1 |
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