Basic scheme of relations between the two networks. Schematic example of the relation between metabolic reaction and metabolic correlation networks. We assume a hypothetical scenario, where a simple chain of biochemical reactions produces strong correlations between the metabolites, which however decrease with the distance of two metabolites in the chain. The bottom part of the figure gives the (hypothetical) reconstructed correlation networks for different regimes of the threshold parameter κ.
Müller-Linow et al. BMC Systems Biology 2007 1:44 doi:10.1186/1752-0509-1-44