BMC Systems Biology

official impact factor 3.57

Open Access Methodology article

A hierarchical approach employing metabolic and gene expression profiles to identify the pathways that confer cytotoxicity in HepG2 cells

Zheng Li1, Shireesh Srivastava1, Xuerui Yang1, Sheenu Mittal1,5, Paul Norton4, James Resau4, Brian Haab4 and Christina Chan1,2,3*

Author Affiliations

1 Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA

2 Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA

3 Department of Computer Science and Engineering, Michigan State University, East Lansing, MI 48824, USA

4 Van Andel Institute, Grand Rapids, MI 49503, USA

5 Department of Biochemistry and Molecular Biology, Michigan State University, USA

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BMC Systems Biology 2007, 1:21 doi:10.1186/1752-0509-1-21

Published: 11 May 2007

Additional files

Additional data file 1:

Metabolic profiles. The data is a table of 27 measured metabolic uptake/productions.

Format: XLS Size: 28KB Download file

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Open Data

Additional data file 2:

BOH regression coefficients. Additional data file 2 is a table listing the regression coefficients of genes to BOH.

Format: XLS Size: 83KB Download file

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Additional data file 3:

TG regression coefficients. Additional data file 3 is a table listing the regression coefficients of genes to TG.

Format: XLS Size: 77KB Download file

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Open Data

Additional data file 4:

BOH linear regression coefficients. Additional data file 4 is a table listing the regression coefficients to BOH with the linear regression model.

Format: XLS Size: 26KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data