Table 3

Performance characteristics of best variables for diagnosis of fatty liver
Test/panel of tests Sensitivity Specificity PPV NPV +LR –LR DOR Accuracy
% 95% CI % 95% CI % 95% CI % 95% CI 95% CI 95% CI 95% CI %
PON 86.7 75.7–94.2 93.5 80.9 –97.5 92.8 81.0–98.3 87.7 72.5–94.4 12.2 4.1–36.7 0.1 0.0–0.2 93.1 21.8 –398.0 90.1
NEFA 92.8 81.3 –97.6 86.9 72.5–98.1 86.6 73.0–94.5 92.0 79.4–98.1 6.9 3.2–14.7 0.0 0.0–0.2 86.6 20.2–371.0 89.7
NEFA+PON 99.7 89.6–99.8 95.2 83.0–99.1 95.4 83.7–99.1 99.7 89.2–99.8 21.0 5.6–78.6 0.0 0.0 –1.1 8440.0 14.6–4871511.6 97.7
NEFA+BHBA 92.8 81.3–97.6 90.9 77.4–96.1 90.6 77.4–97.0 93.0 79.4–98.1 9.5 3.7–24.2 0.0 0.0 – 0.2 123.3 25.8–588.2 91.8
NEFA+BHBA+PON 97.6 87.9–99.5 95.4 83.8–98.6 95.3 83.3–99.2 97.6 85.9–99.8 20.0 5.1–77.4 0.0 0.0–0.1 819.0 71.4–9393.6 96.5
NEFA+BHBA+AST 92.5 79.0–98.1 90.2 75.9–96.8 90.2 77.4–97.0 93.0 78.5–98.0 9.7 3.8–24.7 0.0 0.0–0.2 166.5 28.6–966.1 91.6
NEFA+BHBA+AST+PON 97.5 86.8–99.5 95.4 83.5–98.6 95.1 83.3–99.2 97.6 85.2–99.8 19.4 5.0–75.3 0.0 0.0–0.1 722.0 62.7–8301.8 96.4
NEFA+BHBA+AST+LCAT 94.8 82.7–98.5 90.0 77.4–96.1 90.2 75.4–96.7 94.7 81.3–99.1 9.7 3.8–24.7 0.0 0.0–0.2 166.5 28.6–966.1 92.4
NEFA+BHBA+AST+LCAT+PON 97.4 86.8-99.5 95.0 83.5–98.6 95.0 81.7–99.1 97.4 84.9–99.8 19.4 5.0–75.3 0.0 0.0–0.1 722.0 62.7–8301.8 96.2
NEFA+BHBA+AST+LCAT+T.CHOL 97.4 86.8–99.5 95.0 83.5–98.6 95.0 81.7–99.1 97.4 84.9–99.8 19.4 5.0–75.3 0.0 0.0–0.1 722.0 62.7–8301.8 96.2
NEFA+BHBA+AST+LCAT+T.CHOL+PON 99.7 88.4–99.8 97.2 84.9–99.8 97.2 84.9–99.8 99.7 88.4–99.8 36.4 –5.7–230.2 0.0 0.0–1.2 13898.2 21.1–9140510.2 98.7

NPV, negative predictive value; PPV, positive predictive value; +LR, positive likelihood ratio; –LR, negative likelihood ratio; DOR, diagnostic odd ratio.

The cut-off values used for the tests were ≤ 53.22, 0.39, 1.28, 101.00, 3.31, 2.43 for PON (U/mL), NEFA (mmol/L), BHBA (mmol/L), AST (U/L), LCAT (470/390) and T.CHOL (mmol/L), respectively.

Farid et al.

Farid et al. BMC Veterinary Research 2013 9:73   doi:10.1186/1746-6148-9-73

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