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Open Access Research article

A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice

Wesley M Burnside12, Paul A Flecknell1, Angus I Cameron3 and Aurélie A Thomas1*

Author Affiliations

1 Comparative Biology Centre, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom

2 School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, United Kingdom

3 Boyd Orr Centre for population and ecosystem health, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom

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BMC Veterinary Research 2013, 9:48  doi:10.1186/1746-6148-9-48

Published: 13 March 2013

Additional files

Additional file 1:

Smoothing curves for non-linear relationships. Estimated smoothing curves of the non-linear parameters of the effect of time on pulse rate (PR) and arterial haemoglobin saturation (SpO2), as well as the effect of SpO2 on PR and respiratory rate (fr) determined by a series of generalized additive mixed effects models (GAMMs). Dashed lines represent 95% CI. Significant non-linear relationships occurred for PR (P ≤ 0.0001) and SpO2 (P < 0.0001) as a smoothing function of time, as well as PR (P ≤ 0.0001) and fr (P < 0.0001) as a smoothing function of SpO2.

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Additional file 2:

Plots of vital signs for individual mice. Individual plots of pulse rate (PR), respiratory rate (fr) and arterial haemoglobin saturation (SpO2) for each mouse by after administration of medetomidine-ketamine (MK) or dexmedetomidine-ketamine (DK) by the intraperitoneal (IP) or subcutaneous (SC) route over time used for statistical analysis. The individual mouse identification number is located at the bottom left corner of each plot.

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Open Data