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Open Access Research article

Oxytocin induced oxidative stress in lactating Bubalis bubalis (Nili Ravi)

Zafar Iqbal1, Zia Ur Rahman2*, Faqir Muhammad3, Tanweer Khaliq3, Haseeb Anwar4, Mian Muhammad Awais5 and Saima Sadaf6

Author Affiliations

1 Department of Basic Sciences, sub campus Jhang, University of Veterinary and Animal Sciences, Lahore, Pakistan

2 Sub-Campus Toba Tek Singh, University of Agriculture, Faisalabad, Pakistan

3 Department of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan

4 Department of Physiology, GC University, Faisalabad, Pakistan

5 Department of Pathobiology, sub campus Jhang, University of Veterinary and Animal Sciences, Lahore, Pakistan

6 Government College of Home Economics, Lahore, Pakistan

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BMC Veterinary Research 2013, 9:169  doi:10.1186/1746-6148-9-169

Published: 27 August 2013

Abstract

Background

Oxytocin has been reported for a wide range of adverse effects in different species of lactating animals. The present study was aimed to evaluate the adverse effects of oxytocin on biomarkers of oxidative stress in buffaloes. Lactating buffaloes (n = 40) were randomly selected from a commercial dairy farm located in the peri-urban area of district Faisalabad, Pakistan and divided into two equal groups viz. treatment and control groups, each containing 20 buffaloes. Buffaloes in treatment group were injected with oxytocin before each milking (morning and evening) for milk let down; whereas, animals in control group were milked naturally without oxytocin injection. Both the groups were assessed for oxidative stress biomarkers.

Results

Results showed significantly higher levels (P ≤ 0.05) of TOS, tHcy and ceruloplasmin oxidase activity in lactating buffaloes injected with oxytocin as compared to those of control group. On the other hand, serum levels of TAS, PON1 and arylesterase were significantly lower (P ≤ 0.05) in the buffaloes of treatment group.

Conclusions

Oxytocin injection in lactating buffaloes resulted in elevated oxidative stress by increasing the total homocysteine and ceruloplasmin oxidase activity and decreasing enzymatic activities of antioxidant enzymes including paraoxonase-1 and arylesterase; that might render the animals to poor productive and reproductive potential.

Keywords:
Oxytocin; Oxidative stress; Biomarkers; Lactating buffaloes