Figure 5.

Effects of taurolidine on p53 protein expression. Western blots showing the effects of taurolidine exposure on this cell cycle regulatory protein is concentration and cell line dependent. The taurolidine-induced appearance of p53 protein in D17 cells suggests these cells proceed through a p53-induced apoptotic pathway when exposed to 125 uM taurolidine. In HMPOS cells, with apparent mutant p53, p53 was down-regulated suggesting cell death may occur through different pathways in this cell line. Clone 4 and COS cells did not show any p53 expression at any concentration of taurolidine tested (data not shown).

Marley et al. BMC Veterinary Research 2013 9:15   doi:10.1186/1746-6148-9-15
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