Table 1

Meloxicam pharmacokinetic parameters following a single IV (0.5 mg/kg) or PO (1.0 mg/kg) administration
IV PO
Parameter (Units) Geometric Mean Min Median Max Geometric Mean Min Median Max
AUCextrapolated(%) 1.9 1.4 1.7 3.5 6.6 3.6 6.3 13.1
AUCINF(hr*μg/mL) 43.96 31.44 43.45 55.60 68.35 52.37 74.98 79.24
Cl (mL/min/kg) 0.190 0.151 0.192 0.260 N/A N/A N/A N/A
Cl/F (mL/min/kg) N/A N/A N/A N/A 0.248 0.212 0.230 0.318
C0 (μg/mL) 6.163 5.257 5.930 7.631 N/A N/A N/A N/A
CMAX(μg/mL) N/A N/A N/A N/A 1.314 .826 1.368 1.776
TMAX(hr) N/A N/A N/A N/A 21.4 12.0 24.0 24.0
T ½ λz (hr) 17.4 16.2 16.8 20.7 22.7 18.0 21.9 30.8
λz (1/hr) 0.0398 0.0335 0.0413 0.0428 0.0306 0.0225 0.0316 0.0386
MRT (hr) 20.6 17.7 20.0 26.5 41.7 35.4 40.7 51.3
Vss (L/kg) 0.235 0.206 0.237 0.282 N/A N/A N/A N/A
Vz (L/kg) 0.286 0.213 0.293 0.365 N/A N/A N/A N/A
Vz/F (L/kg) N/A N/A N/A N/A 0.487 0.331 0.464 0.748
Dose (mg/kg) 0.50 0.49 0.50 0.51 1.0 1.0 1.0 1.1
MAT (hr) N/A N/A N/A N/A 20.8 13.9 22.6 24.8
F N/A N/A N/A N/A 0.76 0.48 0.85 0.92

Meloxicam noncompartmental pharmacokinetics (WinNonlin 5.2, Pharsight Inc. Cary NC, USA).

AUC extrapolated = percent of the AUC extrapolated; AUCINF = area under the curve extrapolated to infinity; Cl = plasma clearance; Cl/F = Cl per fraction of the dose absorbed; C0 = Concentration extrapolated to time 0 using log-linear regression of the first two time points; TMAX = time to CMAX; T ½ λz = terminal half-life; λz = terminal rate constant; MRT = mean residence time extrapolated to infinity; Vss = volume of distribution at steady state; Vz = volume of distribution, area method; Vz/F = Vz per fraction of the dose absorbed; MAT = mean absorption time; F = fraction of the dose absorbed.

Kreuder et al.

Kreuder et al. BMC Veterinary Research 2012 8:85   doi:10.1186/1746-6148-8-85

Open Data